Harsh V. Chauhan, PhD
Harsh V. Chauhan, PhD

Harsh V. Chauhan, PhD

Associate Professor
School of Pharmacy and Health Professions

Expertise/Specializations

  • Pharmaceutics, Drug Delivery

Academic Appointments

Department

  • Pharmacy Sciences

Position

  • Associate Professor

Biography

Teaching: Dosage Forms and Drug Delivery Systems (Pharm. D students)
                 Advance Dosage Forms and Drug Delivery Systems (MS students)
                 Research (MS students)
Research: Novel Drug Delivery Systems, Poorly Soluble Compounds
Service: Assessment Committee (Co-Chair)

Publications and Presentations

Books

  • Borde, Shambhavi, Singh Navneet, Chauhan, Dhirender and Chauhan, Harsh; “Solid dosage form: Formulation and Characterization”, Handbook of Space Pharmaceuticals, Springer, ISBN 978-3-319-29346-2  , 2018
  • Prasad, Dev and Chauhan, Harsh; “Excipients Utilized in Ocular Drug Delivery”, Nano Bio Materials for Ophthalmic Drug Delivery, Springer.
     , 2016
  • Chauhan, Harsh; Bernick, Jonathan; Prasad, Dev and Masand, Vijay; “ANN on Target Validation as Robust Tool in Drug Discovery and Development”, Artificial Neural Network for Drug Design, Delivery and Disposition, Edited by Puri, Pathak, Sutariya, Tipparaju, Moreno, Academic Press, Print Book ISBN:9780128015599, eBook ISBN :9780128017449.
     , 2015
  • Prasad, Dev and Chauhan, Harsh; “Nanotoxicity of Polymeric and Solid Lipid Nanoparticles”, in Bio-interaction of Nano Materials, CRC Press, ISBN 9781466582385.
     , 2014
  • Gu, Chong-Hui; Chauhan, Harsh; and Kuldipkumar, Anuj; “Factors Affecting Drug Absorption and Disposition in a System”, Pharmaceutics: Basic Principles and Application to Pharmacy Practice, ISBN: Print Book ISBN: 9780123868909; eBook ISBN: 9780123868916, Elsevier 2013.
     , 2013

Articles

  • Anne Trivino, Ashwini Gumireddy, Fan Meng, Dev Prasad, Chauhan Harsh  "Drug–Polymer Miscibility, Interactions, and Precipitation Inhibition Studies for the Development of Amorphous Solid Dispersions for the Poorly Soluble Anticancer Drug Flutamide", Drug Development and Industrial Pharmacy, 45(8), 1277-1291, 2019
  • Gayathri Heenatigala Palliyage, Somnath Singh, Charles R Ashby, Amit K Tiwari, Harsh Chauhan "Pharmaceutical Topical Delivery of Poorly Soluble Polyphenols: Potential Role in Prevention and Treatment of Melanoma", AAPS PharmSciTech, 20(6), 2019
  • Deepal Vora, Segewkal Heruye, Dunesh Kumari, Catherine Opere, Chauhan Harsh "Preparation, Characterization and Antioxidant Evaluation of Poorly Soluble Polyphenol-Loaded Nanoparticles for Cataract Treatment", AAPS PharmSciTech, 20, 2019
  • Ashwini Gumireddy, Ryann Christman, Dunesh Kumari, Amit Tiwari, E Jeffrey North, Chauhan Harsh "Preparation, Characterization, and In Vitro Evaluation of Curcumin- and Resveratrol-Loaded Solid Lipid Nanoparticles", AAPS PharmSciTech, 20(4), 2019
  • Anne Trivino, Ashwini Gumireddy, Chauhan Harsh "Drug-Lipid-Surfactant Miscibility for the Development of Solid Lipid Nanoparticles", AAPS PharmSciTech, 20(2), 2019
  • K Brake, A Gumireddy, A Tiwari, Chauhan Harsh, D Kumari, "In vivo Studies for Drug Development via Oral Delivery: Challenges, Animal Models and Techniques", Pharmaceutical Analytica Acta, 8(8), 2017
  • Saad, A. Hussain; Amal, A. Sulaiman; Curt, Balch; Chauhan, Harsh; Qasim, M. Alhadidi and Amit, K. Tiwari; Natural Polyphenols in Cancer Chemoresistance", Nutrition and Cancer, 68(6), 879-891, 2016
  • Prasad, Dev; Chauhan, Harsh and Atef, Eman; “Role of Molecular Interactions for Synergistic Precipitation Inhibition of Poorly Soluble Drug in Supersaturated Drug–Polymer–Polymer Ternary Solution”, Molecular Pharmaceutics, 13(3), 756-765, 2016
  • Farah, Shrouq I.; Abdelrahman, Abd Almonem; North, E. Jeffrey and Chauhan, Harsh; “Opportunities and Challenges for Natural Products as Novel Antituberculosis Agents", ASSAY and Drug Development Technologies, 14(1), 29-38, 2016
  • Chauhan, Harsh; Mohapatra, Sarat; Munt, Daniel J; Chandratre, Shantanu and Dash, Alekha. "Physical-Chemical Characterization and Formulation Considerations for Solid Lipid Nanoparticles”, AAPS PharmSciTech, 17(3), 12 pages, 2015
  • Gala, U., Chuong, M. C., Varanasi, R., Chauhan, H. "Characterization and Comparison of Lidocaine-Tetracaine and Lidocaine-Camphor Eutectic Mixtures Based on Their Crystallization and Hydrogen-Bonding Abilities", AAPS PharmSciTech, 16, 528-536, 2015
  • Meng, Fan; Dave, Vivek and Chauhan, Harsh; "Qualitative and Quantitative Methods to Determine Miscibility in Amorphous Drug–Polymer Systems." 
     , European Journal of Pharmaceutical Sciences, 77(2015), 106-111, 2015
  • Meng, F., Dave, V., Chauhan, H. Qualitative and quantitative methods to determine miscibility in amorphous drug-polymer systems, European Journal of Pharmaceutical Sciences, 77, 106-111, 2015
  • Meng, Fan; Gala, Urvi and Chauhan, Harsh; "Classification of Solid Dispersions: Correlation to (i) Stability and Solubility (ii) Preparation and Characterization Techniques”, Drug Development and Industrial Pharmacy, 41(9), 1401-1415, 2015
  • Meng, F., Trivino, A., Prasad, D., Chauhan, H. "Investigation and Correlation of Drug Polymer Miscibility and Molecular Interactions by Various Approaches for the Preparation of Amorphous Solid Dispersions", European Journal of Pharmaceutical Sciences, 71, 12-24, 2015
  • Meng, F., Gala, U., Chauhan, H. Classification of solid dispersions: correlation to (i) stability and solubility (ii) preparation and characterization techniques, Drug Development and Industrial Pharmacy, 1-15, 2015
  • Gala, U. and Chauhan, H. "Principles and Applications of Raman Spectroscopy in Pharmaceutical Drug Discovery and Development", Expert Opinion on Drug Discovery, 10, 187-206, 2015
  • Kathe, N., Henriksen, B., Chauhan, H. "Physicochemical Characterization Techniques for Solid Lipid Nanoparticles: Principles and Limitations", Drug Development and Industrial Pharmacy, 40, 1565-1575, 2014
  • Gala U., Chauhan H., "Test Masking Techniques in Pharmaceutical Industry.", American Pharmaceutical Review, 17(4), 24-29, 2014
  • Chauhan, Harsh, Kuldipkumar, Anuj, Barder, Timothy, Medek, Ales, Gu, Chong-Hui, Atef, Eman Correlation of Inhibitory Effects of Polymers on Indomethacin Precipitation in Solution and Amorphous Solid Crystallization Based on Molecular Interaction, Pharmaceutical research, 31, 500-515, 2014
  • D. Prasad, H. Chauhan, "Excipinets Utilized in Ocular Drug Delivery.", Journal of Doctoral Nursing Practice, 2014
  • Masand, V. H., Mahajan, D. T., Hadda, T. B.., Chavan, H., Bandgar, B. P., & Chauhan, H. "Molecular Docking and Quantitative Structure-Activity Relationship (QSAR) Analyses of Indolylarylsulfones as HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors.", Medicinal Chemistry Research, 23(1), 4174-425, 2014
  • Meng F., Trivino A., Prasad D., Chauhan H. Investigation and Correlation of Drug Polymer Miscibility and Molecular Interactions by Various Approaches for the Preparation of High Drug Loading Amorphous Solid Dispersions., Journal of Pharmaceutical Sciences, 2014
  • Gala, U., Choung M., Varanasi R., Chauhan H., Characterization and Comparison of Lidocaine-Tetracaine and Lidocaine-Camphor Eutectic Mixtures Based on their Crystallization and Hydrogen Bonding Abilities., AAPS PharmSciTech, 2014
  • Prasad, D., Chauhan, H., & Atef, E. "Studying the Effect of Lipid Chain Length on the Precipitation of Poorly Water Soluble Drug from Self-Emulsifying Drug Delivery System on Dispersion into Aqueous Medium.", Journal of Pharmacy and Pharmacology, 65(8), 1134-1144, 2013
  • Chauhan, H., Hui-Gu, & Atef, E. "Correlating the Behavior of Polymers in Solution as Precipitation Inhibitor to its Amorphous Stabilization Ability in Solid Dispersions.", Journal of Pharmaceutical Sciences, 102(6), 1924-1935, 2013
  • Gu Chong-Hui, Chauhan H., Kuldipkumar Anuj, "Factors Affecting Drug Absorption and Disposition in a System," Pharmaceutics: Basic Principles and Application to Pharmacy Practice., Elsevier, 2013
  • Grana, A., Limpach, A., & Chauhan, H.,"Formulation Considerations and Applications of Solid Liipid Nanoparticles.", American Pharmaceutical Review, 16(1), 19-25, 2013
  • Prasad, D., & Chauhan, H., (2013). Key Targeting Approaches for Pharmaceutical Drug Delivery., American Pharmaceutical Review, 16(6), 64-70, 2013
  • Atef, Eman, Chauhan, H., Prasad, Dev, Kumari, Dunesh, "Quantifying Solid Mixture of Alpha and Beta Indomethacin Using Raman and Differential Scanning Calorimetry." Doi: 10.5402/2012/9892806, ISRN Chromatography, 2012, Article ID 892806, 6 pages, 2012
  • Atef, E., Chauhan, H., Ceresia, M. & Pidgeon, C. "Using Raman Spectroscopy in Tablet Moisture Surface Analysis: Tablet Surface Markers.", Journal of Pharmaceutical and Biomedical Analysis, 53(4), 852-859, 2010

Editing and Reviews

  • Gala, U., Pham H., Chauhan, H., (2013) Pharmaceutical Applications of Eutectic Mixtures. 2:e130. doi: 10.4172/2329-6631.1000e130 (Editorial), J. Develop Drugs, 2(3), 2 pages, 2013

Presentations

  • Chauhan, H., Gala U., Meng F., Characterization of Binary (Drug-Polymer) and Ternary (Drug-Drug-Polymer) Solid Dispersions: Role of Low Polymer Concentrations on Their Stabilization, AAPS Annual Meeting and Exposition, San Diego, CA, 2014
  • Gala U., Chauhan H., Characterization of Lidocaine-Tetracaine and Lidocaine-Camphor Eutectic Mixtures Based on their Hydrogen Bonding and Crystallization Abilities. AAPS Annual Meeting and Exposition., 2014
  • Gala U., Chauhan, H., Characterization and Comparison of Lidocaine-Tetracaine and Lidocaine-Tetracaine Hydrocholorida Eutectic Mixtures. St. Albert's Research Day, Omaha, 2014
  • Gala U., Chauhan H., Eutectic Mixtures and their Crystallization Ability: Exploration of a Lesser Delved Correlation, Midwest Student Biomedical Research Forum, Omaha, 2014
  • Anne Trivino, Bernick Jonathan, Chauhan, H., Molecular Modeling of Drug Polymer Interactions for Amorphous Stabilization of Poorly Soluble Anticancer Drug Flutamide, AAPS annual meeting, 2013
  • Chauhan H., Chuong, Monica, Varanasi, Ravi, Characterization of Lidocaine-Tetracaine and Lidocaine-Tetracaine HCI Mixtures for Transdermal Delivery, AAPS Annual Meeting., 2013
  • Kathe, N.J., Hass E.J., Chauhan H., Fujita J., Henrikson B.S., Synthesis and Holistic Characterization of Glucogenic Amino Acid Complexes as Ergogenic Aids. AAPS Annual Meeting, 2013
  • Prasad Dev., Chauhan H., Eman Atef, Synergistic Effect of Molecularly Interacting Polymers in Stabilization Ternary Solid Dispersions. AAPS Annual Meeting, 2013
  • Meng F., Chauhan H., Key physicochemical factors for amorphization of poorly water soluble drugs in solid dispersion. Creighton's Annual University Research Day, Omaha, 2013
  • Meng, F., Chauhan, H., Development of amorphous sold dispersion formulations of curcumin. Midwest Student Biomedical Research Forum, Omaha, 2013
  • Chauhan H., Novel Drug Delivery Systems for Poorly Soluble Compounds. Augustana College, Sioux City, SD, 2013
  • Jonathan P. Bernick, Anne Trivino, Chauhan H., Molecular modeling of drug polymer interactions: Correlation to precipitation inhibition and amorphous stabilization of poorly soluble anticancer drug; ACS regional meeting, Omaha, 2012
  • Trivino, Anne, Bernick, Jonathan P., Chauhan, H., Effect of Lipids and Surfactant Miscibility on the Particle Size of Flutamide Solid Lipid Particles. ACS Regional Meeting, 2012
  • Dev Prasad, Chauhan, H., Eman Atef, Understanding drug-polymer interactions for the amorphous stabilization of high melting crystalline compound with various polymers, 244 ACS National meeting, 2012
  • Nagarsenker, M., Chauhan, H., Thermal Characterization of Solid Lipid Nanoparticles containing Gelucire 44/14 and Gelucire 50/13, AAPS Annual Meeting, 2012
  • Chandratre Shantanu, Chauhan H., Dash, Alekha K., Crystallization Inhibition of GMO-Chitosan Nanoparticles during Lyophilization process. AAPS Annual meeting, 2012
  • Prasad Dev., Chauhan H., Atef Eman., Stabilization of Ternary Solid Dispersions at High Drug Load using Molecularly Interacting Polymers. AAPS Annual meeting, 2012
  • Chauhan, H., Physicochemical properties based computational predictions to classify drugs as glass formers, AAPS Annual Meeting, 2012
  • Prasad D., Chauhan H., Eman Atef. Stabilization of Ternary Solid Dispersions at High Drug Load Using Molecularly Interacting Ploymers. AAPS Annual Meeting., 2012
  • Bernick Johnathan, Chauhan, H., In-silico predictions for the development of poorly soluble amorphous drugs, Midwest student biomedical research forum, 2012
  • Chandratare Shantanu, Dhapare Sneha, Chauhan, H., Solubilization and stabilization of poorly soluble drugs, Nebraska EPSCoR, 2011
  • Dev Prasad, Bernick Jonathan, Chauhan H., In-silico Predictions for the Development of Poorly Soluble Anticancer Drugs as Amorphous Systems, 244 ACS National Meeting., 2011
  • Chauhan H., Mohapatra Sarat, Mistry Pinal, Munt Dan, Dash Alekha, Physical characterization of Glyceryl Monooleate (GMO) during lyophilisation process. AAPS annual meeting, 2011
  • Prasad, Dev, Chauhan, H., Atef Eamn, Investigating the effect of various oils on precipitation inhibition of indomethacin from self emulsifying drug delivery systems (SEDDS) on In-vitro dilution. AAPS annual meeting, 2010
  • Atef Eman, Chauhan, H. Prasad Dev, Quantifying Solid Mixture of Alphas and Beta Indomethacin Using Raman and Differential Scanning Calorimetry, AAPS annual meeting, 2010
  • Chauhan H., Prasad Dev, Atef Eman, Gu Chong-Hui, Preparation and characterization of acidic, basic and neutral drug solid dispersions with various polymers having different physicochemical propertie, AAPS-NERDG meeting, 2010

Research and Scholarship

Research and Scholarship Interests

Current Research Projects

  • Pharmaceutical and Nutraceutical Drug Delivery Systems, Poorly Soluble Compounds, Combination Delivery

Grant Funding Received

  • Bulk Paracellular Transport of Drug Carriers in the Nasal Cavity - Health Future Foundation, Creighton University - PI: Dr. Anthony Kincaid, Co-PI: Dr. Justin Tolman.
  • Novel Oral Delivery Systems for Anticancer Phytochemical Curcumin Creighton Undergraduate Research and Scholarship funds (CURAS), Creighton University
  • Development of Oral Drug Delivery Systems for Poorly Soluble Anticancer Drugs Based on Drug-Polymer Interactions - Dr. George F. Haddix President's Faculty Research Fund, Creighton University, Creighton University

Awards and Honors

  • Scholarly Achievement Award, School of Pharmacy and Health Professions, Creighton University, 2015
  • Travelship Award, American Association of Pharmaceutical Scientists (AAPS), 2014