E. Jeffrey . North, BS, PhD
E. Jeffrey North, BS, PhD

E. Jeffrey North, BS, PhD

Assistant Professor
School of Pharmacy and Health Professions

Expertise/Specializations

  • Medicinal Chemistry

Academic Appointments

Department

  • Pharmacy Sciences

Position

  • Assistant Professor

Teaching Activity

  • MPS 531 Chemical Basis of Drug Action I
  • MPS 531 Chemical Basis of Drug Action II
  • MPS 602 Analytical Aspects of Pharmaceutical Sciences Research
  • PHA 337 Chemical Basis of Drug Action I
  • PHA 337 Chemical Basis of Drug Action II

Education

  • B.S. Chemistry, The University of Memphis
  • M.S. Chemistry, The University of Memphis
  • Ph.D. Organic Chemistry, The University of Memphis

Publications and Presentations

Articles

  • Laura Fleck, E. Jeffrey North, Richard Lee, Lawrence Mulcaha, Gabriele Casadei, Kim Lewis, A Screen and Validation of Prodrug Antimicrobials, Antimicrobial Agents and Chemotherapy, 58(3), 1410-1419, 2014
  • Michael La Fleur, Lingmei Sun, Ida Lister, John Keating, Andra Nantel, Lisa Long, Mahmoud Ghannoum, Jeffrey North, Richard Lee, Ken Coleman, Thomas Dahl, Kim Lewis, Potentiation of Azole Antifungals by 2-Adamantanamine, Antimicrobial Agents and Chemotherapy, 57(8), 3585-3592, 2013
  • E. Jeffrey North, Mary Jackson, Richard E. Lee, New Approaches to Target the Mycolic Acid Biosynthesis Pathway, Current Pharmaceutical Design, 2013
  • Michael S. Scherman, Elton J. North, Victoria Jones, Tammara N. Hess, Anna E. Grzegorzewicz, Takeo Kasagami, In-Hae Kim, Oleg Merzlikin, Anne J. Lenaerts, Richard E. Lee, Mary Jackson, Christophe Morisseau, and Michael R. McNeil, Screening a Library of 1,600 Adamantyl Ureas for Anti-Myhcobacterium Tuberculosis Activity in Vitro and for Better Physical Chemical Properties for Bioavailability, Bioorganic & Medicinal Chemistry, 20(10), 3255-3262, 2012
  • Anna E. Grzegorzewicz, Ha Pham, Vijay Gundi, Michael S. Scherman, E. Jeffrey North, Tamara Hess, Victoria Jones, Veronica Gruppo, Sarah E. Born, J. Kordulakova, S.S. Chavadi, Chistophe Morisseau, Anne J. Lenaerts, Richard E. Lee, Michael R. McNeil. Mary Jackson, Inhibition of Mycolic Acid Transport across the Mycobacterium Tuberculosis Plasma Membrane., Nature Chemical Biology, 8(4), 334-341, 2012
  • Joshua R. Brown, Elton J. North, Julian G. Hurdle, Christophe Morisseau, Jerrod S. Scarborough, Dianquing Sun, Jana Kordulakova, Michael S. Scherman, Victoria Jones, Anna Grzegorzewicz, Rebecca M. Crew, Mary Jackson, Michael R. McNeil, Richard E. Lee, The Structure Activity Relationship of Urea Derivatives as Anti-Tuberculosis Agents, Bioorganic & Medicinal Chemistry, 19(18), 5585-5595, 2011

Presentations

  • "Design, Synthesis and Structure Activity Relationships of Adamantyl Ureas as Anti-tuberculosis Agents, " Spring 2013 Seminar Series, University of Memphis, Department of Chemistry,, 2013
  • "Design, Synthesis and Biological Assessment of Adamantyl Ureas as Anti-tuberculosis Agents with Improved Selectivity and Pharmacokinetic Factors," Gordon Research Conference, New Antibacterial Discovery & Development, Lucca (Barga), Italy, April 2012., 2012
  • "Design Synthesis and Biological Evaluation of Adamantyl Ureas as Anti-tuberculosis Agents," Gordon Research Conference, TB Drug Development, Lucca (Barga), Italy, 2011
  • "Computer-guided Discovery of Autotaxin Inhibitors," 240th American Chemical Society National Meeting, Boston, Massachusetts., 2010

Research and Scholarship

Research and Scholarship Interests

  • Medicinal chemistry Computational modeling In vitro pharmacokinetic analysis

Current Research Projects

  • Discovery and development of novel anti-microbial agents

Awards and Honors

  • Educator of the Year, Pharmacy Distance Class 2017, 2014
  • Novel Diverse Lead Compound Autotaxin Inhibitors, 2011