Elton J. North, BS, PhD
Elton J. North, BS, PhD

Elton J. North, BS, PhD

Assistant Professor
School of Pharmacy and Health Professions

Expertise/Specializations

  • Medicinal Chemistry

Academic Appointments

Department

  • Pharmacy Sciences

Position

  • Assistant Professor

Teaching Activity

  • MPS 531 Chemical Basis of Drug Action I
  • MPS 532 Chemical Basis of Drug Action II
  • MPS 602 Analytical Aspects of Pharmaceutical Sciences Research
  • PHA 337 Chemical Basis of Drug Action I
  • PHA 447 Chemical Basis of Drug Action II

Publications and Presentations

Articles

  • A.N. Pandya, P.K. Prathipati, P. Hegde, W. Li, K.F. Graham, S. Mandal, K.M. Drescher, C.J. Destache, D. Ordway, M. Jackson, E.J. North, Indole-2-carboxamides are Active Against an Acute Mycobacterium abscessus Infected Mouse Model, Antimicrobial Agents and Chemotherapy, [Epub ahead of print], 2019
  • W. Li, A. Yazidi, A.N. Pandya, P. Hegde, W. Tong, V. Calado Nogueira de Moura, E.J. North, J. Sygusch, M. Jackson, MmpL3 as a Target for the Treatment of Drug-Resistant Nontuberculous Mycobacterial Infections, Frontiers in Microbiology, 9, 1547, 2018
  • N.D. Franz, J.M. Belardinelli, M.A. Kaminski, L.C. Dunn, V. Calado Nogueira de Moura, M.A. Blaha, D.D. Truong, W. Li, M. Jackson, E.J. North, Design, synthesis and evaluation of indole-2-carboxamides with pan anti-mycobacterial activity, Bioorganic & Medicinal Chemistry, 25(14), 3746-3755, 2017
  • A.N. Pandya, E.M. Villa, E.J. North, A simple and efficient approach for the synthesis of 2-aminated quinazoline derivatives via metal free oxidative annulation, Tetrahedron Letters, 58(13), 1276-1279, 2017
  • W. Li, A. Sanchez-Hidalgo, V. Jones, V. Calado Nogueira de Moura, E.J. North, M. Jackson, Synergistic interactions of MmpL3 inhibitors with antitubercular compounds in vitro, Antimicrobial Agents and Chemotherapy, 61(4), e02399-16, 2017
  • W. Li, A. Obregon-Henao, J.B. Wallach, E.J. North, R.E. Lee, M. Gonzalez-Juarrero, D. Schnappinger, M. Jackson, Antimicrobial Agents and Chemotherapy, 60(9), 5198-5207, 2016
  • S.I. Farah, A.A. Abdelrahman, E. Jeffrey North, H. Chauhan, Opportunities and Challenges for Natural Products as Novel Antituberculosis Agents, ASSAY and Drug Development Technologies, 14(1), 29-38, 2016
  • A.E. Grzegorzwicz, N. Eynard, A. Quemard, E. Jeffrey North, A. Margolis, J.J. Lindenberger, V. Jones, J. Kordulakova, P.J. Brennan, R.E. Lee, D.R. Ronning, M.R. McNeil, M. Jackson, Covalent Modification of the Mycobacterium tuberculosis FAS-II dehydratase by Isoxyl and Thiacetazone, ACS Infectious Diseases, 1(2), 91-97, 2015
  • W. Li, A. Upadhyay, F.L. Fontes, E. Jeffrey North, Y. Wang, D.C. Crans, A.E. Grzegorzewicz, V. Jones, S.G. Franzblau, R.E. Lee, D.C. Crick, M. Jackson, Novel Insights into the Mechanism of Inhibition of MmpL3, a Target of Multiple Pharmacophores in Mycobacterium tuberculosis, Antimicrobial Agents and Chemotherapy, 58(11), 6413-6423, 2014
  • Ekaterina Gavrish, Binu Shrestha, Chao Chen, Ida Lister, E. Jeffrey North, Lei Yang, Richard E. Lee, Angel Han, Bronwyn Williams, David Chamuska, Ken Coleman, Kim Lewis, Michael LaFleur, In vitro and in vivo Activity of HPi1, a Selective Antimicrobial against Helicobacter pylori, Antimicrobial Agents and Chemotherapy, 58(6), 3255-3260, 2014
  • Laura Fleck, E. Jeffrey North, Richard Lee, Lawrence Mulcaha, Gabriele Casadei, Kim Lewis, A Screen and Validation of Prodrug Antimicrobials, Antimicrobial Agents and Chemotherapy, 58(3), 1410-1419, 2014
  • E. Jeffrey North, Mary Jackson, Richard E. Lee, New Approaches to Target the Mycolic Acid Biosynthesis Pathway, Current Pharmaceutical Design, 20(27), 4357-78, 2014
  • Michael LaFleur, Lingmei Sun, Ida Lister, John Keating, Andra Nantel, Lisa Long, Mahmoud Ghannoum, Jeffrey North, Richard Lee, Ken Coleman, Thomas Dahl, Kim Lewis, Potentiation of azole antifungals by 2-adamantanamine, Antimicrobial Agents and Chemotherapy, 57(8), 3585-3592, 2013
  • E. Jeffrey North, Michael S. Scherman, David F. Bruhn, Jerrod S. Scarborough, Marcus M. Maddox, Victoria Jones, Anna Grzegorzewicz, Lei Yang, Tamara Hess, Christophe Morisseau, Mary Jackson, Michael R. McNeil, Richard E. Lee, Design, synthesis and anti-tuberculosis activity of adamantyl heteroaryl ureas with improved in vitro and in vivo pharmacokinetic properties, Bioorganic & Medicinal Chemistry, 21(9), 2587-2599, 2013
  • Michael S. Scherman, Elton J. North, Victoria Jones, Tammara N. Hess, Anna E. Grzegorzewicz, Takeo Kasagami, In-Hae Kim, Oleg Merzlikin, Anne J. Lenaerts, Richard E. Lee, Mary Jackson, Christophe Morisseau, and Michael R. McNeil, Screening a library of 1,600 adamantyl ureas for anti-Mycobacterium tuberculosis activity in vitro and for better physical chemical properties for bioavailability, Bioorganic & Medicinal Chemistry, 20(10), 3255-3262, 2012
  • Anna E. Grzegorzewicz, Ha Pham, Vijay Gundi, Michael S. Scherman, E. Jeffrey North, Tamara Hess, Victoria Jones, Veronica Gruppo, Sarah E. Born, J. Kordulakova, S. S. Chavadi, Christophe Morisseau, Anne J. Lenaerts, Richard E. Lee, Michael R. McNeil, Mary Jackson, Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane, Nature Chemical Biology, 8(4), 334-341, 2012
  • Joshua R. Brown, Elton J. North, Julian G. Hurdle, Christophe Morisseau, Jerrod S. Scarborough, Dianquing Sun, Jana Korduláková, Michael S. Scherman, Victoria Jones, Anna Grzegorzewicz, Rebecca M. Crew, Mary Jackson, Michael R. McNeil, Richard E. Lee, The Structure Activity Relationship of Urea Derivatives as Anti-Tuberculosis Agents, Bioorganic & Medicinal Chemistry, 19(18), 5585-5595, 2011
  • E. Jeffrey North, Angela L. Howard, Irene W. Wanjala, Truc Chi T. Pham, Daniel L. Baker, Abby L. Parrill, Pharmacophore Development and Application in Identifying Bioavailable Autotaxin Inhibitors, Journal of Medicinal Chemistry, 53(8), 3095-3105, 2010
  • E. Jeffrey North, Daniel A. Osborne, Peter K. Bridson, Daniel L. Baker, Abby L. Parrill, Autotaxin Structure-Activity Relationships Revealed through Lysophosphatidylcholine Analogs, Bioorganic & Medicinal Chemistry, 17(9), 3433-3442, 2009
  • Truc-Chi T. Pham, James I. Fells Sr., Daniel A. Osborne, E. Jeffrey North, Mor M. Naor, Abby L. Parrill, Molecular recognition in the sphingosine 1-phosphate receptor family, Journal of Molecular Graphics and Modelling, Journal of Molecular Graphics & Modelling, 26(8), 1189-1201, 2007

Presentations

  • "Design, Synthesis and Structure Activity Relationships of Adamantyl Ureas as Anti-tuberculosis Agents, " Spring 2013 Seminar Series, University of Memphis, Department of Chemistry,, 2013
  • "Design, Synthesis and Biological Assessment of Adamantyl Ureas as Anti-tuberculosis Agents with Improved Selectivity and Pharmacokinetic Factors," Gordon Research Conference, New Antibacterial Discovery & Development, Lucca (Barga), Italy, April 2012., 2012
  • "Design Synthesis and Biological Evaluation of Adamantyl Ureas as Anti-tuberculosis Agents," Gordon Research Conference, TB Drug Development, Lucca (Barga), Italy, 2011
  • "Computer-guided Discovery of Autotaxin Inhibitors," 240th American Chemical Society National Meeting, Boston, Massachusetts., 2010

Research and Scholarship

Research and Scholarship Interests

  • Medicinal chemistry Computational modeling In vitro pharmacokinetic analysis

Current Research Projects

  • Discovery and development of novel anti-microbial agents

Grant Funding Received

  • Discovery of therapeutics to treat non-tuberculous mycobacterial infections, Cystic Fibrosis Foundation, Pilot & Feasibility Award
  • Discovery of in vivo small molecules for hearing protection against cisplatin and noise, National Institutes of Health, R01
  • MmpL3 as a Target for Novel anti-TB agents, National Institutes of Health, R01
  • Developing Therapeutics to Treat Non-tuberculous Mycobacteria Infections, Creighton University, Health Science Strategic Investment Fund Faculty Development Grant
  • Discovery and Development of Therapeutics to Treat Non-tuberculous Mycobacterial Infections, Creighton University, Jack and Lois Wareham Research Award
  • The Identification and Optimization of Novel Anti-tuberculosis Agents, Creighton University Office of Research and Compliance Services, LB 692
  • Discovery of Novel Anti-Mycobacterium tuberculosis FadD32 Inhibitors, American Association of Colleges of Pharmacy, New Investigator Award

Awards and Honors

  • Recipient of the 2018 Dr. Robert Heaney Graduate Research Mentor Award, Creighton University , 2018
  • Indole-based Therapeutics, 2018
  • Recipient of the 2017 Scholarly Achievement Award, Creighton University, 2017
  • Recipient of the 2017 Educator of the Year Award, Pharmacy Campus Class 2019, 2016
  • Recipient of the 2015 Educator of the Year Award, Pharmacy Distance Class 2017, 2014
  • Novel Diverse Lead Compound Autotaxin Inhibitors, 2011