| Proposed Graduate Courses in Pharmaceutical Sciences |
| MPS 692 Directed Independent Study (1-5) |
| Supervised independent projects that may include laboratory work, assigned readings, research papers, etc. Available in toxicology, biopharmaceutics, medicinal chemistry, pharmacodynamics and pharmacokinetics. P: Undergraduate or graduate stdg. & DC. |
| MPS 693 Directed Independent Research (1-5) |
| Supervised independent research for motivated students to become involved in ongoing original research projects of the pharmaceutical sciences faculty. P: Undergraduate or graduate stdg. & DC. |
| MPS 617 Advanced Pharmaceutics (3) |
| This course will provide an in-depth study of the physical and chemical principles which are involved in the development, formation and stabilization of selected pharmaceutical dosage forms for optimization of drug bioavailability and therapeutic utility. |
| MPS 622 Advanced Medicinal Chemistry (3) |
| This course will build upon the scientific foundation laid by the Chemical Basis of Drug Action professional course sequence. The structure-activity relationships of complex drug molecules will be investigated and discussed. Students as well as faculty will be involved in presenting information on the chemically important aspects of drug delivery, stability, receptor affinity and selectivity, metabolic vulnerability and distribution. |
| MPS 633 Research Methods (3) |
| Laboratory rotations in which graduate students perform or observe methods used in pharmaceutical and administrative sciences research. The value of the methods and their applications to the research efforts of the pharmaceutical sciences faculty are described in detail. P: DC. |
| MPS 635 Advanced Toxicology (3) |
| An in-depth consideration of principles, concepts and molecular mechanisms of toxicity. The current status of toxicologic principles concerned with public health, drugs, food technology, veterinary medicine and agriculture will be examined. P: DC. |
| MPS 665 Advanced Pharmacokinetics (2) |
| Computer modeling of the absorption, distribution, metabolism, and excretion of drugs will be the core of the course content. Multicompartmental analysis, non-compartmental analysis as well as non-linear kinetics will be discussed. Development of a pharmacokinetic protocol through the various phases of INDA submission as well as in vitro - in vivo correlations will be considered. |
| MPS 675 Solid Delivery Systems (3) |
| The course uses a physical chemistry approach to solving the problems associated with practical design of solid dosage forms as well as those associated with their evaluation. |
| MPS 676 Disperse Systems (3) |
| The course uses a physical chemistry approach to solving the problems associated with practical design of disperse system dosage forms as well as those associated with their evaluation. |
| MPS 677 Macromolecular Systems (3) |
| The course uses a physical chemistry approach to solving the problems associated with the manufacture, evaluation and utilization of polymers in the design of drug delivery systems as well as macromolecules as drugs. |
| MPS 691 Pharmaceutical Sciences Seminar (1-3) |
| Seminar in selected subjects for pharmaceutical sciences graduate students. P: DC. |
| MPS 797 Master's Directed Independent Research (1-4) |
| Supervised original research. P: DC. |
| MPS 799 Master's Thesis (1-8) |
| Review of the literature and research data; writing of the thesis. Student must register for this course in any term when engaged in formal preparation of the Master's thesis; however, six credit hours are the maximum applicable toward the degree. P: DC. |
| Graduate Courses in the Department of Pharmacology |
| PHR 537 Rational Drug Design and Discovery (2) |
| Scientific basis for the rational design and development of new drug molecules. Discussion of drug-receptor theory, structure activity relationships, and specific examples of the design of new drugs. P: DC. |
| PHR 723 Drug Metabolism and Disposition (2) |
| An in-depth consideration of the various factors which influence the metabolism and disposition of drugs and foreign elements. The influence of physiological factors, physico-chemical factors, genetic factors, pathological factors, inducers, activators, inhibitors, co-oxidation, regioselectivity and stereoselectivity on drug metabolism will be addressed. The importance of various cytochrome P-450 isoenzymes and their metabolic specificities will be considered. P: DC. |
| PHR 711 Receptor and Molecular Pharmacology (3) |
| Exhaustive treatment of receptor and molecular pharmacology that considers historical development of concepts, radioligand receptor binding, drug-receptor interactions, receptor characterization and isolation, and signal transduction. P: PHS 601; BCH 600 or DC. |
| PHR 715 Advanced Pharmacology (3) |
| Discussion of recent advances in the pharmacology of cardiovascular, autonomic and central nervous systems. Comprehensive review of drug classes including discussions on possible mechanisms by which drugs produce functional effects in these systems. P: Gr. stdg.; PHR 631; or DC |
| PHR 717 Molecular Biology in Pharmacology (2) |
| A survey course in molecular biology and relevant techniques. The course is geared to pharmacologists and others in medical and scientific fields seeking fundamental knowledge of this area. The goal is to provide an understanding of the theoretical and practical aspects of molecular biology for use in research. P: DC. |
| PHR 790 Research Methods in Pharmacology (1-5) |
| Laboratory rotations in which graduate students perform or observe methods used in pharmacological research. The value of the method and its application to the research efforts of the pharmacology faculty are described in detail. P: DC. |
| PHR 595 Directed Independent Study (1-5) |
| Supervised independent research for motivated students to become involved in ongoing original research projects of the pharmacology faculty. P: Undergraduate or graduate stdg. and DC. |
| PHR 597 Directed Independent Study (1-5) |
| Supervised independent research for motivated students to become involved in ongoing original research projects of the pharmacology faculty. P: Undergraduate or graduate stdg. and DC. |
| Graduate Courses in Other Departments |
| Biomedical Sciences: |
| BMS 603 Cell Biology (4) |
| Detailed consideration of the functional aspects of cell biology, with an emphasis on eukaryotic cells. Topics include signal transduction, neuronal cell biology, synthesis, transport and processing of secretory proteins, extracellular matrix proteins , cell adhesion, cytoskeleton. P: IC |
| BMS 604 Molecular Biology (4) |
| Detailed consideration of the structure, function and synthesis of DNA, RNA and proteins, focusing on the eukaryotic cell. Topics include DNA structures, transcription, translation, replication, recombinant DNA technology, eukaryotic viruses and the control of cellular differentiation in normal and pathophysiology states such as cancer. Emphasis will be given to the most current advances. P: IC. |
| BMS 605 Molecular Endocrinology (3) |
| Study of the function of endocrine glands at the organismal, cellular and molecular level. 3C & D. P: BMS 601 or equiv. or IC. |
| BMS 606 Proteins: Structure-Function Relationships (4) |
| Topics covered include primary structure, principles of secondary and tertiary structures, enzyme kinetics, chemical modifications and their effects, protein-protein interactions, protein complementation and prediction of conformation. Presentation and model building by students are integral parts of this course. 4R.. P: BMS 521 or 600 or equiv. |
| BMS 607 Enzymes (4) |
| Classification and properties of enzymes, kinetics, activators and inhibitors. Study of selected enzymes to demonstrate general principles. 3R. P: BMS 521 or 600 or equiv. and BMS 606. |
| BMS 608 Peptide Chemistry (4) |
| A detailed study of the theoretical and practical aspects of peptide synthesis, isolation, purification and structure. P: IC and BMS 521 or BMS 600 or equiv. |
| BMS 609 Biochemistry of Lipids (4) |
| Systematic study of the structure and function of lipids and steroids in biological systems. Topics include identification, biosynthesis and function of lipids in membrane structure, as metabolic fuel and as regulators of metabolism. 3R. P: BMS 521 or 600. |
| BMS 610 The Carbohydrates (3) |
| Structure, function and metabolism of carbohydrate-containing macromolecules. P: IC. |
| Medical Microbiology: |
| MIC 615 Medical Microbiology and Immunology (5) |
| Basic instruction in the biology of microorganisms, host-parasite relationships, infectious diseases, immunobiology and immunopathology, bacteriology, virology, parasitology, mycology, molecular genetics, and antimicrobial agents and chemotherapy. Required of all graduate students. 5R&L arr. |
| MIC 739 Microbial Physiology (4) |
| Study of molecular and sub-cellular processes in microorganisms. Includes molecular structure and function, cell division, synthesis of macromolecules, and metabolism. 4R. L arr. P: IC. |
| MIC 753 Antimicrobial Agents and Chemotherapy (4) |
| Chemistry, pharmacology, and biology of antibiotic substances and their use in therapy of infectious diseases. P: MIC 615 or IC. |
| MIC 727 Methods in Medical Microbiology and Immunology (3) |
| Study of modern methods of bioinstrumentation as related to medical microbiology. Laboratory and group discussion dealing with the assay of bacterial components and bioactive products. |
| MIC 746 Advanced Immunology (3) |
| Lectures and conferences providing a coordinated and detailed account of current immunology at an advanced level. Students will be expected to familiarize themselves with the original literature, and emphasis will be given to the more rapidly progressing areas. 3R&L arr. P: MIC 543 or IC. |
| Chemistry: |
| CHM 501 Inorganic Chemistry I (2) |
| Relation of atomic and molecular structure to chemical and physical properties. Periodicity and descriptive chemistry of inorganic classes and groups. Topics covered include group theory, MO theory, molecular and ionic structures, redox reactions, acid/base theories, and coordination compounds. Laboratory (3 hours weekly); descriptive inorganic chemistry. P: CHM 331. |
| CHM 502 Inorganic Chemistry II (2) |
| Additional topics in inorganic chemistry. Emphasis on organometallic chemistry of transition metals, molecular binding, synthesis and chemical reactivities of inorganic and organometallic compounds. P: CHM 501. |
| CHM 506 Environmental Chemistry and Natural Resources (3) |
| The nature, identification, and quantitative determination of air and water pollutants. Study of natural resources and energy production. Topics covered include the atmosphere, ozone, the troposphere, natural water, acid rain, drinking water, metals, organochlorine compounds and waste management. P: CHM 208 or DC. |
| CHM 521 Synthetic Organic Methods (3) |
| A contemporary survey of the analysis, design, and execution of new methods and innovative total synthesis in organic chemistry. Approaches and techniques for critical reading, discussion, and application of the literature of organic chemistry will be introduced and developed. P: CHM 323. |
| CHM 523 Bioorganic Chemistry (3) |
| A survey of current topics at the boundary between organic chemistry and biology, with emphasis on the role of organic reactions in biological systems. The current chemical literature will serve as source material for study and discussion. P: CHM 323. |
| CHM 524 Advanced Techniques in Organic Chemistry (3) |
| Advanced techniques in organic and inorganic chemistry with emphasis on synthetic methods. Introduction to the literature of chemistry. Development of skills in information-finding through manual and computer-assisted searches. 1R, 6L. P: CHM 323 & 324. |
| CHM 525 Organic Spectroscopic Analysis (3) |
| A study of infrared, nuclear magnetic resonance (13C and 1H), ultraviolet, and mass spectrometry. The principles of spectrometry are treated along with principles of operation of each technique and the use of each method in the elucidation of molecular structure. P: CHM 323. |